Biochips for Electrophysiology

Multi-electrode array (MEA) biochips are used to stimulate and record extracellular electrical activity of excitable biological tissue from as many as 60 recording sites simultaneously. In most cases, single unit activity and/or slow field potentials are recorded in preparations such as dissociated cell cultures (neurons, heart muscle cells) and organotypic or acute tissue slices (brain, spinal cord, retina, etc.). In the drug discovery process, the use of MEA technology in secondary screening will provide more in depth information on the systems biology response.

The Ayanda™ MEA biochips are fabricated on transparent microchips and are adapted to the commercially available MEA60 signal amplification and data acquisition system from Multi Channel Systems MCS (Reutlingen, Germany). We offer various micro-electrode geometries on the Ayanda™ MEA biochips ranging from planar to 3D tip-shaped electrodes.

The unique Ayanda™ 3D MEA biochip, which includes tip-shaped micro-electrodes, enables improved and more reliable electrophysiological experimentation with acute brain slices. The publication by M. Heuschkel et al., J. Neurosci. Methods 114 (2002) 135-148 provides a detailed discussion of this product and its characteristics.

Custom-designed MEA Biochips

We can also offer upon request user-specific solutions in terms of MEA-layout configuration. Ayanda™ MEA biochips can be adapted to other amplification and data acquisition systems. We would be pleased to provide a quote upon request. Click here to find out more about customised MEA biochips.

More Information

Please find more information about the Ayanda™ MEA biochips at the following links:
• Available single-well MEA biochips
  
• Multi-well MEA biochips
• MEA biochips applications
  
• MEA biochip technology references
  
  
• Please find more documentation on our download page